Douglas G. Metcalf, Ph.D.


Doug works with clients in the biotechnology, pharmaceutical and medical device industries on a wide range of intellectual property projects that focus on building and leveraging patent portfolios.

He drafts and prosecutes patent applications related to peptide and protein pharmaceuticals, therapeutic antibodies, small molecule immunotherapeutics, aminoglycoside antibiotics, vaccines, adoptive cell transfer therapy (TILs, CAR-Ts), chimeric antigen receptors (CARs), gene therapy, CRISPR, induced pluripotent stem cells (iPSCs), microbiome engineering, sustained-release drug delivery devices, needle and cannula devices, medical diagnostics, next-generation sequencing (NGS), circulating cell-free DNA/RNA (cfDNA, ctDNA, miRNA), drug screens, cell-based assays, animal models and synthetic biology. He is experienced at coordinating patent prosecution across multiple jurisdictions and leveraging foreign law to maximize global assets.

Prior to beginning his legal career, Doug obtained his Ph.D. in Biochemistry & Molecular Biophysics with William F. DeGrado and Joel S. Bennett at the University of Pennsylvania’s Perelman School of Medicine. His research included rational protein design (including the de novo design of aqueous proteins, membrane proteins, self-assembling proteins and cofactor-binding proteins), solid-phase peptide synthesis, the development of molecular modeling software, protein structure prediction, protein dynamics modeling, sequence- and data-based bioinformatics, design and cloning of recombinant genes, site-directed mutagenesis, recombinant protein expression and purification, protein mass spectroscopy, tissue culture, immunoassays and fluorescence activated cell sorting (FACS). Doug solved an NMR structure in collaboration with A. Joshua Wand, and he worked at Penn’s Gene Therapy Vector Core with Jim Wilson and Carl June where he cloned gene therapy vectors. He served on Penn’s Provost Council of Research and on the search committee that selected Vice Provost for Research Perry Molinoff, who oversaw Penn’s research infrastructure from 2003 to 2007, supporting $700 million in research awards. He chaired the George W. Raiziss Biochemical Rounds seminar series, which invites leading scientists including Nobel laureates to Penn to present their research. He subsequently accepted a postdoctoral fellowship at the Indiana University School of Medicine’s Riley Heart Research Center where his research included the microdissection of transgenic mouse embryos, in-situ hybridization, immunostaining, FACS, RT-qPCR and microarray transcriptome analyses.

Following his scientific career, Doug served as a nonaffiliated member on the Partners HealthCare Institutional Review Board where he reviewed clinical research conducted at Massachusetts General Hospital, Brigham and Women’s Hospital and McClean Hospital. He interned with Magistrate Judge Marianne B. Bowler at the U.S. District Court for the District of Massachusetts.


  • Boston University School of Law  (J.D., cum laude)
  • University of Pennsylvania Perelman School of Medicine  (Ph.D.)
    • Biochemistry and Molecular Biophysics
  • Washington and Lee University  (B.S., cum laude)
    • Chemistry and Biology (double major)

Bar Admissions

  • Massachusetts
  • U.S. Patent & Trademark Office
  • Michigan (pending)